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IV Therapy NCLEX Practice Quiz

Test your knowledge of IV therapy with these challenging NCLEX-style questions focused on clinical scenarios, patient safety, and critical thinking.

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Anonymous
Published December 30, 2025

Quiz Questions & Answers

Review every prompt, the correct responses, and helpful context to prep for your own run-through.

Question 1: A nurse is caring for a patient receiving TPN through a central line. The patient suddenly develops shortness of breath, chest pain, and anxiety. Which action should the nurse take FIRST?

Obtain a 12-lead ECG

Stop the TPN infusion immediately

Administer supplemental oxygen

Call for a rapid response team

Question 2: A patient's IV site shows redness, warmth, and a cord-like vein extending 3cm above the insertion site. The nurse identifies this as:

Phlebitis

Infiltration

Extravasation

Cellulitis

Question 3: While administering blood products, a patient develops urticaria and complains of itching. After stopping the transfusion, which medication should the nurse prepare to administer?

Epinephrine

Diphenhydramine

Hydrocortisone

Acetaminophen

Question 4: A patient's IV pump suddenly alarms with 'Air-in-Line.' The nurse notes a 2cm air bubble in the tubing. What is the minimum volume of air that could cause a fatal air embolism?

0.5 mL

3-5 mL

10 mL

20 mL

Question 5: A nurse is preparing to administer vancomycin. The patient's previous dose caused Red Man Syndrome. Which intervention is most appropriate?

Cancel the medication

Extend the infusion time to 2 hours

Switch to oral antibiotics

Administer through a central line

Question 6: A patient with a central line develops sudden fever, chills, and hypotension during IV antibiotic administration. The nurse's priority action should be:

Obtain blood cultures

Stop the infusion and disconnect the line

Administer acetaminophen

Check vital signs

Question 7: A patient requires multiple IV medications. Which medication must be administered through a dedicated line?

Heparin

Lipids

Antibiotics

Normal saline

Question 8: A patient's IV site shows blanching, coolness, and decreased pulse distal to insertion. The nurse recognizes this as:

Infiltration

Phlebitis

Arterial occlusion

Venous thrombosis

Question 9: A nurse is calculating the flow rate for an IV medication. The order is for 1000mL over 8 hours. The drop factor is 15 drops/mL. What is the correct drops per minute?

31 drops/minute

28 drops/minute

35 drops/minute

42 drops/minute

Question 10: A patient with a PICC line reports pain and swelling in the arm. The nurse notes edema and distended neck veins. What complication should the nurse suspect?

Superior vena cava syndrome

Deep vein thrombosis

Cellulitis

Lymphedema