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Multiple Sclerosis (MS) High-Yield NCLEX Practice

Test your knowledge on the clinical manifestations, nursing interventions, and management strategies for patients with Multiple Sclerosis.

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Mageto
Published April 11, 2026

Quiz Questions & Answers

Review every prompt, the correct responses, and helpful context to prep for your own run-through.

Question 1: A nurse is performing an admission assessment on a client with a new diagnosis of Multiple Sclerosis (MS). Which clinical manifestation should the nurse expect to find?

Lead-pipe rigidity and bradykinesia

Ascending paralysis starting in the lower extremities

Vision loss and tingling sensations in the extremities

Ptosis and improved muscle strength with rest

Question 2: The nurse is providing discharge teaching to a client with Multiple Sclerosis. Which instruction is most important to include to prevent exacerbations?

Limit fluid intake to 1,000 mL per day.

Perform high-impact aerobic exercise daily.

Avoid hot baths and saunas.

Ensure you get at least 4 hours of sleep per night.

Question 3: A client with Multiple Sclerosis is prescribed Baclofen. Which outcome indicates the medication is effective?

Resolution of blurry vision

Improved short-term memory and cognition

Decreased muscle spasticity and frequency of spasms

Increased heart rate and blood pressure

Question 4: Which nursing diagnosis is the highest priority for a client with MS experiencing dysphagia and significant fatigue?

Social Isolation

Knowledge Deficit

Risk for Aspiration

Impaired Physical Mobility

Question 5: A client with MS reports a 'shock-like' sensation that travels down the spine when flexing the neck forward. How should the nurse document this finding?

Babinski reflex

Lhermitte’s sign

Romberg's sign

Brudzinski’s sign

Question 6: The nurse is caring for a client with MS who has developed urinary retention. Which intervention should the nurse implement first?

Perform a bladder scan to assess residual volume.

Encourage the client to drink caffeinated beverages.

Administer a prescribed diuretic.

Insert a permanent indwelling catheter.

Question 7: A client with MS is experiencing an acute exacerbation. Which class of medication does the nurse anticipate administering to reduce inflammation?

Methylprednisolone (Corticosteroids)

Non-steroidal anti-inflammatory drugs (NSAIDs)

Antibiotics

Anticonvulsants

Question 8: When teaching a client with MS about energy conservation, which strategy should the nurse recommend?

Use a shower chair and rest between activities.

Complete all heavy household chores in the morning.

Avoid using a wheelchair or walker to maintain strength.

Nap for 3 to 4 hours in the late afternoon.

Question 9: A client with MS is frustrated by frequent 'mood swings' and episodes of uncontrollable laughing or crying. How should the nurse explain this to the client?

It results from damage to the areas of the brain that control emotions.

It is likely a sign of early-onset dementia.

It is a side effect of the muscle relaxants.

It is a normal reaction to a chronic illness diagnosis.

Question 10: Which diagnostic test is considered the most definitive for identifying the plaques associated with Multiple Sclerosis?

Electroencephalogram (EEG)

Magnetic Resonance Imaging (MRI)

Electromyography (EMG)

Computed Tomography (CT) scan